Article

Genome-wide Transcriptome Study in Skin Biopsies Reveals an Association of E2F4 With Cadasil and Cognitive Impairment

2020-06-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold>CADASIL is a small vessel disease caused by mutations in <italic>NOTCH3 </italic>that lead to an odd number of cysteines in the receptor, causing protein misfolding and aggregation. The main symptoms are migraine, psychiatric disturbances, recurrent strokes and dementia, as executive function is characteristically impaired. The molecular pathways altered by this...

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Literature Corpus work: a0c5b150-f46a-5456-ab6c-653cee7f5b7c
DOI: 10.21203/rs.3.rs-32722/v1

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