Article

mTOR inhibition alleviates CD8+ T-cell senescence in activated phosphoinositide 3-kinase δ syndrome 2 patients

2023-04-19

Abstract excerpt

<h4>Background: </h4> We investigated the clinical and immunological features in a Chinese cohort of activated phosphatidylinositol 3-kinase δ syndrome 2 (APDS2) and assessed the efficacy of Rapamycin therapy and the underlying mechanism. <h4>Results: </h4> The shared clinical manifestation of patients included recurrent respiratory tract infection, lymphadenopathy, persistent or recurrent splenomegaly, and hepato...

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Literature Corpus work: 9d8a6a8f-a87e-5f67-894d-d20eeab7e233
DOI: 10.21203/rs.3.rs-2781253/v1

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