Article

Prodromal pathogenesis of CLN7 Batten Disease revealed by multimodal biomarkers in macaques

2025-12-05

Abstract excerpt

Neuronal ceroid lipofuscinosis type 7 (CLN7) is a devastating paediatric neurodegenerative disorder with no cure and limited natural history data to guide therapeutic development. Here, we present the first multimodal characterization of prodromal and early-stage CLN7 disease in Japanese macaques carrying a spontaneous CLN7 −/− mutation. Using structural T 2 -weighted MRI for volumetry, [ 18 F]FDG PET for gluc...

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Literature Corpus work: 9c7bac95-2a94-538c-92a3-e4a68f11c21b
DOI: 10.64898/2025.12.02.691930

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