Article

PDIA6 acts as a prognostic biomarker and immune regulator in HNSCC with novel insights into EBV associated nasopharyngeal carcinoma

2026-06-25

Abstract excerpt

<title>Abstract</title> <p> Background Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous malignancy with poor prognosis. The role of protein disulfide isomerase A6 ( <italic>PDIA6</italic> ) in HNSCC, particularly in Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC), remains unclear. The present study aimed to investigate the expression, prognostic value and biological function...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b1ba0b7-6b30-5b8d-8a03-b2f6c6b4ef42
DOI: 10.21203/rs.3.rs-9644255/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PDIA6 acts as a prognostic biomarker and immune regulator in HNSCC with novel insights into EBV associated nasopharyngeal carcinomaDOI 10.21203/rs.3.rs-9644255/v1Read

PDIA6 promotes immune escape of head and neck squamous cell carcinoma by regulating TIGIT/CD155 axisSemantic proximity Read

Deciphering nasopharyngeal carcinoma pathogenesis via proteomicsSemantic proximity Read

Protein Disulfide-Isomerase A3 Is a Robust Prognostic Biomarker for Cancers and Predicts the Immunotherapy Response EffectivelySemantic proximity Read

Nasopharyngeal carcinoma: molecular biomarker discovery and progress.Semantic proximity Read

The Ubiquitin–Proteasome System is an Important Driver of EBV-Associated Nasopharyngeal Carcinoma Progression: A Meta-Analysis of Transcriptomics DataSemantic proximity Read

Gene Signatures and Prognostic Values of m6A Genes in Nasopharyngeal CarcinomaSemantic proximity Read

Identification of Key Biomarkers and Potential Therapeutic Drugs in Nasopharyngeal Carcinoma Based on Comprehensive Bioinformatics AnalysisSemantic proximity Read

Bioinformatic identification of candidate biomarkers and related transcription factors in nasopharyngeal carcinomaSemantic proximity Read

PDIA6 promotes glioma malignancy by activating the IRE1α- p-HSP27 signaling axisSemantic proximity Read

PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathwaySemantic proximity Read

Comprehensive Analysis of Endoplasmic Reticulum Stress Related signature in Head and Neck Squamous CarcinomaSemantic proximity Read

PDIA3 correlates with clinical malignant features and immune signature in human gliomas.Semantic proximity Read