A layered standards framework for integrating single-cell and spatial omics data into brain cell atlases

Abstract excerpt

The BRAIN Initiative Cell Atlas Network (BICAN) is generating large-scale multimodal datasets to profile cell types in the human, non-human primate, and mouse brain. The diversity of single-cell and spatial transcriptomic and epigenomic assays, combined with varied experimental contexts, multiple data-generating laboratories and distributed infrastructure, poses substantial challenges for data integration and reus...

Topics

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• Cancer Genomics and Diagnostics
• Cells
• Clonal Evolution
• Machine Learning
• Models, Biological
• Neonatal Respiratory Health Research
• Phenotype
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

98e3a96a-0d5f-5bb5-91f0-e03e88757d8f

DOI

10.64898/2026.04.30.722039