Article

The treatment of Tofacitinib for rosacea through the inhibition of the JAK/STAT signaling pathway

2024-07-19

Abstract excerpt

<title>Abstract</title> <p>Rosacea is a chronic inflammatory skin disease characterized by facial erythema and telangiectasia. Despite ongoing research, the pathogenesis of rosacea remains incompletely understood, and current therapies are not entirely satisfactory. The JAK/STAT signaling pathway plays an essential role in immunoregulation, inflammation, and neurovascular regulation. Inhibition of the JAK/STAT pa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 982acf11-3a64-5a57-be2d-31e36cd5ce4b
DOI: 10.21203/rs.3.rs-4645719/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The treatment of Tofacitinib for rosacea through the inhibition of the JAK/STAT signaling pathwayDOI 10.21203/rs.3.rs-4645719/v1Read

Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition.Semantic proximity Read

Cathelicidin LL-37-Induced Transcriptome of Human Keratinocyte Identifies Chemokine CXCL10 Link to T-Cell-Mediated Rosacea Pathogenesis through Jak1/STAT1 PathwaySemantic proximity Read

Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosaceaSemantic proximity Read

Keratinocyte-Immune Cell Crosstalk in a STAT1-Mediated Pathway: Novel Insights Into Rosacea PathogenesisSemantic proximity Read

Recent advances in understanding and managing rosaceaSemantic proximity Read

Integrative concepts of rosacea pathophysiology, clinical presentation and new therapeutics.Semantic proximity Read

Activation of Janus kinase signaling pathway in acne lesionsSemantic proximity Read

Inhibidores de JAK: usos en dermatología. Parte 2: aplicaciones en psoriasis, dermatitis atópica y otras dermatosisSemantic proximity Read

DNAJB2 Attenuates Rosacea Skin Inflammation and Angiogenesis by Inhibiting the Endoplasmic Reticulum Stress-mediated TLR2/Myd88/NF-κB pathwaySemantic proximity Read

Efficacy and safety of tofacitinib in treatment of pemphigus: a single-center cohort studySemantic proximity Read

Cefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinaseSemantic proximity Read

Upadacitinib: Mechanism of action, clinical, and translational scienceSemantic proximity Read