Article

Bayesian Semiparametric Model for Pathway-Based Analysis with Zero-Inflated Clinical Outcomes

2016-12-01

Abstract excerpt

In this paper, we propose a semiparametric regression approach for identifying pathways related to zero-inflated clinical outcomes, where a pathway is a gene set derived from prior biological knowledge. Our approach is developed by using a Bayesian hierarchical framework. We model the pathway effect nonparametrically into a zero-inflated Poisson hierarchical regression model with an unknown link function. Nonparam...

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Identifiers and source

Literature Corpus work: 972bdc52-09b9-5388-a232-92cb19b7433e
DOI: 10.1007/s13253-016-0264-3

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