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Harnessing the Power of Physiologically Based Pharmacokinetic Modeling to Explore Potential Discordance between in vitro Dissolution, Local Gut vs Systemic Bioequivalence in Health and Disease: The Case of Budesonide in Crohn’s Disease

2023-08-04

Abstract excerpt

The most common method for establishing bioequivalence (BE) is to demonstrate similarity of concentration-time profiles in the systemic circulation, as a surrogate to the site of action. However, the similarity, or otherwise, of profiles from two different formulation in the gastrointestinal tract (GIT) may not be associated with same conclusions based on systemic circulation. Here, we have explored the concordanc...

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Literature Corpus work: 9588745f-008f-5f18-b316-f0e2a3083de3
DOI: 10.20944/preprints202308.0400.v1

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Harnessing the Power of Physiologically Based Pharmacokinetic Modeling to Explore Potential Discordance between in vitro Dissolution, Local Gut vs Systemic Bioequivalence in Health and Disease: The Case of Budesonide in Crohn’s DiseaseDOI 10.20944/preprints202308.0400.v1Read

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