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Development of the genetic toolkit identifies capsular polysaccharides as a competitive colonization factor in <i>Ruminococcus gnavus</i>

2025-08-13

Abstract excerpt

Ruminococcus gnavus is a commensal bacterium in the human gut associated with various diseases, and its abundance often increases in the intestines of patients with active inflammatory bowel disease (IBD). However, the genetic factors that establish gut colonization and virulence remain elusive due to the lack of a system for genetic modification. This study develops several genetic tools, including a shuttle vect...

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Identifiers and source

Literature Corpus work
950938a7-2297-59b8-a758-9b338e1abdbd
DOI
10.1101/2025.08.12.669022
Open publication

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Development of the genetic toolkit identifies capsular polysaccharides as a competitive colonization factor in <i>Ruminococcus gnavus</i>DOI 10.1101/2025.08.12.669022
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