Article

Microbial Adaptation in Healthy Ageing: Insights from Age-associated Structural Variation in the Human Gut Microbiome

2025-07-29

Abstract excerpt

<title>Abstract</title> <p>In this metagenome-wide association study, we profiled 14,249 structural variants (SVs) in the gut microbiome of 10,215 individuals from five cohorts (four European and one African). This revealed 105 SVs that exhibited replicable associations with host chronological age across the different cohorts, with Oscillibacter sp. ER4 and Alistipes shahii emerging as key species. A comparison o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94f5f961-c60e-5d05-9339-c0b1b04972e3
DOI: 10.21203/rs.3.rs-5633858/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microbial Adaptation in Healthy Ageing: Insights from Age-associated Structural Variation in the Human Gut MicrobiomeDOI 10.21203/rs.3.rs-5633858/v1Read

Gut Microbiome Pattern Reflects Healthy Aging and Predicts Extended Survival in HumansSemantic proximity Read

Adjusting for age improves identification of gut microbiome alterations in multiple diseasesSemantic proximity Read

Ecological and Genomic Variation of the Gut Microbiome in Gastrointestinal Compromised Human Cohort Across Different AgesSemantic proximity Read

Elevated gut microbiome abundance of Christensenellaceae, Porphyromonadaceae and Rikenellaceae is associated with reduced visceral adipose tissue and healthier metabolic profile in Italian elderlySemantic proximity Read

Evolutionary history and gut microbial genome size in health and diseaseSemantic proximity Read

Functional metagenomic profiling of intestinal microbiome in extreme ageingSemantic proximity Read

Taxonomic and metabolic development of the human gut microbiome across life stages: a worldwide metagenomic investigationSemantic proximity Read

Utilization of Host and Microbiome Features in Determination of Biological AgingSemantic proximity Read

The Oral Microbiome Is a Population-Scale Readout of the Exposome, Age, and Systemic HealthSemantic proximity Read

Healthy and Unhealthy Aging and the Human MicrobiomeSemantic proximity Read

A Novel Index for Predicting Health Status Using Species-level Gut Microbiome ProfilingSemantic proximity Read

Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and CentenariansSemantic proximity Read