Article

EAGLE-AI: A large language model workflow for automated extraction and scoring of literature evidence linking genes to autism spectrum disorder

2025-09-12

Abstract excerpt

We previously developed the Evaluation of Autism Gene Link Evidence (EAGLE) curation framework and used it to characterise 219 autism-associated genes. However, this took years of human work. We present EAGLE-AI, an automated curation system incorporating large language models (LLMs). On screened paper sets, it achieves F1 91% and scoring error 17.2%, near human performance. EAGLE-AI performs worse on unscreened p...

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Literature Corpus work: 946f1afc-5261-5e75-8e1f-c66a983cf94e
DOI: 10.1101/2025.09.10.25334730

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