Translating CRISPR-Cas Systems into musculoskeletal medicine and orthopaedics: a scoping review protocol

Abstract excerpt

<h4>Background</h4> Musculoskeletal diseases are a leading cause of global disability and healthcare burden, yet traditional orthopaedic procedures often fail to address molecular drivers of degenerative and genetic conditions. CRISPR-Cas Systems, a precise and programmable genome-editing technology, show promise in preclinical musculoskeletal models, ranging from gene knockouts in osteoarthritis to mutation corr...

Topics

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• Clustered Regularly Interspaced Short Palindromic Repeats
• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Gene Editing
• Gene Expression Regulation
• Genetic Testing
• Genetic Therapy
• Rheumatic Diseases

Identifiers and source

Literature Corpus work

91fd8ab9-012e-5a07-8795-535393af8855

DOI

10.1101/2025.09.14.25335710