Back to search

Article

Regulatory Role of Long Non-Coding RNA “Maternally-Expressed Gene-3” in Diabetic Nephropathy through Targeting microRNA-21 and Transforming Growth Factor-Beta

2022-03-01

Abstract excerpt

<title>Abstract</title> <p><bold>Introduction:</bold> Diabetic nephropathy (DN) is a leading cause of chronic kidney disease and end-stage renal disease worldwide. The maternally expressed gene-3 (MEG3), a lncRNA, is implicated in the development of diabetic microvascular complications like retinopathy and nephropathy. MicroRNA-21 (miRNA-21) and Transforming Growth Factor-Beta (TGF-β) are established playmakers i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9081f8db-a057-5803-81b1-43edccab32c5
DOI
10.21203/rs.3.rs-1374466/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Regulatory Role of Long Non-Coding RNA “Maternally-Expressed Gene-3” in Diabetic Nephropathy through Targeting microRNA-21 and Transforming Growth Factor-BetaDOI 10.21203/rs.3.rs-1374466/v1
Long non-coding RNA MEG3 promotes fibrosis and inflammatory response in diabetic nephropathy via miR-181a/Egr-1/TLR4 axisSemantic proximity
The potential role of lncRNAs in diabetes and diabetic microvascular complicationsSemantic proximity
Diabetic nephropathy--emerging epigenetic mechanisms.Semantic proximity
Long Noncoding RNAs and Their Therapeutic Promise in Diabetic NephropathySemantic proximity
The Genetic Variants of Long Noncoding RNA MEG3 and Its Association to the Clinical Features of Diabetic Retinopathy.Semantic proximity
LncRNA as a regulator in the development of diabetic complicationsSemantic proximity
Long Noncoding RNAs as Diagnostic and Therapeutic Targets in Type 2 Diabetes and Related ComplicationsSemantic proximity
Construction of a novel miRNA regulatory network and identification of target genes in gestational diabetes mellitus by integrated analysisSemantic proximity
Long Noncoding RNAs in the Pathogenesis of Diabetic Kidney Disease: Implications for Novel Therapeutic StrategiesSemantic proximity
A Big Role for microRNAs in Gestational Diabetes MellitusSemantic proximity
EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative StressSemantic proximity
Non-Coding RNA in Type 2 Diabetes Cardio–Renal Complications and SGLT2 Inhibitor ResponseSemantic proximity
Select a neighboring publication to make it the new centre.