Article

Competitive exclusion strengthens selection for transmissibility and increases the benefit of recombination for within-host adaptation

2020-06-18

Abstract excerpt

Pathogens experience selection at multiple scales, given the need to transmit between hosts and replicate within them. This presents the challenge of cross-scale selective conflict when adaptations to one scale compromise fitness at another, such as mutations that improve transmissibility but make individuals less competitive within hosts. Selection operates differently at these scales, with tight transmission bot...

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Identifiers and source

Literature Corpus work: 90808fd2-47f7-5ca1-98ba-502b83cf2606
DOI: 10.1101/2020.06.18.158956

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