Article

Activating PIK3CA Mutations of Adipose-derived Stem Cells Drive Mutant-like Phenotypes of Wild-type Cells in Macrodactyly

2024-12-18

Abstract excerpt

<title>Abstract</title> <p>Background Pathological adipose proliferation is one of characteristic manifestations of macrodactyly. Although PIK3CA gain-of-function mutations are known to impact adipose-derived stem cells (ADSCs) in macrodactyly, their effects on adjacent wild-type cells are poorly understood. Methods We utilized conditioned medium and transwell systems to investigate the influence of macrodactyl...

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Literature Corpus work: 9032833c-02ad-5e9b-9847-163d72788461
DOI: 10.21203/rs.3.rs-5358068/v1

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