Back to search

Article

The I-SPY COVID Adaptive Platform Trial for COVID-19 Acute Respiratory Failure: Rationale, Design and Operations

2022-05-07

Abstract excerpt

<h4>Introduction</h4> The COVID-19 pandemic brought an urgent need to discover novel effective therapeutics for patients hospitalized with severe COVID-19. The ISPY COVID trial was designed and implemented in early 2020 to evaluate investigational agents rapidly and simultaneously on a phase 2 adaptive platform. This manuscript outlines the design, rationale, implementation, and challenges of the ISPY COVID trial...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9007c9a5-0cd6-5406-ac1a-d8adae6b9755
DOI
10.1101/2022.05.05.22274628
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The I-SPY COVID Adaptive Platform Trial for COVID-19 Acute Respiratory Failure: Rationale, Design and OperationsDOI 10.1101/2022.05.05.22274628
Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3)Semantic proximity
Determining the return on investment of a global adaptive platform trial for critically ill patients during COVID-19: A value of implementation analysis in low- and middle-income countries and globallySemantic proximity
The West Africa Lassa fever Consortium pre-positioned protocol for a Phase II/III adaptive, randomised, controlled, platform trial to evaluate multiple Lassa fever therapeuticsSemantic proximity
Quality Assessment of 45 Guidelines on Management of Critical Care Patients with COVID-19: A Systematic Review and AGREE II Instrument AssessmentSemantic proximity
Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomized controlled adaptive platform trial of treatments for acute SARS-CoV-2 infection in community settingsSemantic proximity
Determining the return on investment of a global adaptive platform trial for critically ill patients during COVID-19: A value of implementation analysis in low- and middle-income countries and globallySemantic proximity
Effect of Paxlovid Treatment During Acute Covid-19 on Long Covid Onset: An EHR-Based Target Trial Emulation from the N3C and RECOVER ConsortiaSemantic proximity
The COVID-19 Critical Care Consortium observational study: Design and rationale of a prospective, international, multicenter, observational studySemantic proximity
Assessing the Secondary Use and Scientific Impact of Shared Clinical Trial Data: A Cross-Sectional Study of Clinical Trials Shared on the YODA Project PlatformSemantic proximity
Comparative effectiveness of Paxlovid versus sotrovimab and molnupiravir for preventing severe COVID-19 outcomes in non-hospitalised patients: observational cohort study using the OpenSAFELY platformSemantic proximity
Efficacy and Safety of AYUSH-64 in COVID-19: A Systematic Review and Meta-AnalysisSemantic proximity
HBOT, hyperinflammatory burden, comorbidity burden and drug exposure in relation to repeated-measures respiratory severity in hospitalized adults with COVID-19: a post hoc secondary analysis of a randomized clinical trialSemantic proximity
Select a neighboring publication to make it the new centre.