Article

Evidences of a cytotoxic activity of S-adenosylmethionine on OCI-AML3 cells

2014-05-08

Abstract excerpt

<h4>Background</h4> The acute myeloid leukemia (AML) cell line OCI-AML3, carrying both NPM1 mutation A and the heterozygous DNMT3A R882C mutation, represents the model for in vitro studies on AML with mutated NPM1 1 . AML with mutated NPM1 harbours a hypo-methylated profile distinct from those of the other AML subtypes 2 . This characteristic is probably related to the inhibitory effect of the mutant DNMT3A on...

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Literature Corpus work: 8f5d6b82-5b52-5fe6-a9ac-8c41366c2103
DOI: 10.1101/004978

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