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Severe Expressive Language Impairment and Infection-Associated Dystonic Deterioration with Multidomain Improvement After Levodopa Initiation in SHANK3-Related Disorder: A Case Report and Focused Literature Review

2026-08-14

Abstract excerpt

SHANK3-related disorder within the Phelan-McDermid syndrome spectrum is clinically heterogeneous and commonly includes severe expressive language impairment, hypotonia, motor coordination difficulties, sensory features, sleep disturbance, reduced pain expression, and regression in a subset of affected individuals. However, a potential dystonic contribution to expressive language impairment, orofacial dysfunction,...

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Literature Corpus work: 8dd27c7f-4f18-5bd8-8c9b-aa04c7d5ccae
DOI: 10.20944/preprints202608.0983.v1

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Severe Expressive Language Impairment and Infection-Associated Dystonic Deterioration with Multidomain Improvement After Levodopa Initiation in SHANK3-Related Disorder: A Case Report and Focused Literature ReviewDOI 10.20944/preprints202608.0983.v1Read

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