Article

Bispecific antibody neutralizes circulating SARS-CoV-2 variants, prevents escape and protects mice from disease

2021-01-22

Abstract excerpt

<h4>Summary</h4> Neutralizing antibodies targeting the receptor binding domain (RBD) of the SARS-CoV-2 Spike (S) are among the most promising approaches against coronavirus disease 2019 (COVID-19) 1,2 . We developed a bispecific, IgG1-like molecule (CoV-X2) based on two antibodies derived from COVID-19 convalescent donors, C121 and C135 3 . CoV-X2 simultaneously binds two independent sites on the RBD and, unlik...

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Identifiers and source

Literature Corpus work: 890e084e-00c2-5534-bbdb-a12301124625
DOI: 10.1101/2021.01.22.427567

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