Article

A Noninvasive Skin Biopsy of Free Nerve Endings via Realtime Third-Harmonic Microscopy

2022-12-16

Abstract excerpt

Skin biopsy was the only method to provide free-intraepidermal-nerve-endings (FINEs) structural information for the differential diagnosis of small fiber neuropathy (SFN). Its invasive nature was particularly unfavorable for patients with diabetic coagulation abnormalities thus there is an unmet clinical need for a non-invasive FINEs imaging tool. Here we show a tightly-focused epi-Third-harmonic-generation micros...

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Literature Corpus work: 88c17e08-231b-5704-855f-fa40e04576cb
DOI: 10.1101/2022.12.14.520369

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