Article

<i>Porphyromonas gingivalis</i> activates Heat-Shock-Protein 27 to drive a LC3C-specific probacterial form of select autophagy that is redox sensitive for intracellular bacterial survival in human gingival mucosa

2024-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Porphyromonas gingivalis , a major oral pathobiont, evades canonical host pathogen clearance in human primary gingival epithelial cells (GECs) by initiating a non-canonical variant of autophagy consisting of Microtubule-associated protein 1A/1B-light chain 3 (LC3)-rich autophagosomes, which then act as replicative niches. Simultaneously, P. gingivalis inhibits apoptosis and oxidative-stress, in...

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Literature Corpus work: 848b071e-c780-55f9-bf96-693e9973b081
DOI: 10.1101/2024.07.01.601539

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