Article

Perturbation-Aware Neural ODE (pNODE) Learns Microbiome Dynamics from Clinical Data and Predicts Gut-Borne Bloodstream Infections in Patients Receiving Cancer Treatment

2025-12-01

Abstract excerpt

Disruption of the gut microbiota during cancer treatment, particularly in allogeneic hematopoietic cell transplantation (allo-HCT), is a major contributor to adverse clinical outcomes, including gut-borne bloodstream infections. Accurately forecasting microbial population dynamics under clinical perturbations, such as antibiotic administration, could inform treatment strategies that reduce the risk of infection. H...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 844b5f82-1407-578f-88c4-002e0214c492
DOI: 10.1101/2025.11.26.690798

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Perturbation-Aware Neural ODE (pNODE) Learns Microbiome Dynamics from Clinical Data and Predicts Gut-Borne Bloodstream Infections in Patients Receiving Cancer TreatmentDOI 10.1101/2025.11.26.690798Read

Deep Learning Enables Design of Multifunctional Synthetic Human Gut Microbiome DynamicsSemantic proximity Read

Identification of dynamic models of microbial communitiesSemantic proximity Read

Microbial dynamics inference at ecosystem-scaleSemantic proximity Read

Ecological Modeling from Time-Series Inference: Insight into Dynamics and Stability of Intestinal MicrobiotaSemantic proximity Read

System Biology Modeling with Compositional Microbiome Data Reveals Personalized Gut Microbial Dynamics and Keystone SpeciesSemantic proximity Read

Antibiotic-induced shifts in fecal microbiota density and composition during hematopoietic stem cell transplantationSemantic proximity Read

The MTIST platform: a microbiome time series inference standardized test simulation, dataset, and scoring systemsSemantic proximity Read

Wastewater-informed neural compartmental model for long-horizon case number projectionsSemantic proximity Read

Antibiotic-Induced Shifts in Fecal Microbiota Density and Composition during Hematopoietic Stem Cell TransplantationSemantic proximity Read

Linear scaling reveals low-dimensional structure in observable microbial dynamicsSemantic proximity Read

DynaBiome: Interpretable Unsupervised Learning of Gut Microbiome Dysbiosis using Temporal Deep ModelsSemantic proximity Read

Integrating Kolmogorov-Arnold Networks with Ordinary Differential Equations for Efficient, Interpretable and Robust Deep Learning: A Case Study in the Epidemiology of Infectious DiseasesSemantic proximity Read