Article

A hepatocyte-specific cytochrome <i>c</i> oxidase deficiency in mice leads to a lymphopenia owing to deficiencies in bone marrow progenitors

2024-09-02

Abstract excerpt

<h4>Summary</h4> Mutations that negatively impact mitochondrial function are highly prevalent in humans and lead to disorders with a wide spectrum of disease phenotypes, including deficiencies in immune cell development and/or function. Previous analyses of mice with a hepatocyte-specific cytochrome c oxidase (COX) deficiency revealed an unexpected peripheral blood leukopenia associated with splenic and thymic a...

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Literature Corpus work: 7a86f025-375d-5a82-b00c-13c0d78417b7
DOI: 10.1101/2024.08.30.609186

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