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A broad-spectrum antiviral fusion protein, Pheromonicin demonstrated protective efficacy against SARS-CoV-2 variants in vitro and in vivo models

2022-03-31

Abstract excerpt

The unprecedented coronavirus disease (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective antiviral drug to control this severe infectious disease. Here, we found that the E, or M membrane proteins of coronavirus could be targeted by a 28-residue antibody mimetic by fusing two antibody Fab complementarity-determining regions (VHCDR1 and VLCDR3) t...

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Literature Corpus work
7942b05a-ea37-516a-9744-1d02fbbf7645
DOI
10.21203/rs.3.rs-1475652/v1
Open publication

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A broad-spectrum antiviral fusion protein, Pheromonicin demonstrated protective efficacy against SARS-CoV-2 variants in vitro and in vivo modelsDOI 10.21203/rs.3.rs-1475652/v1
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