Comprehensive single cell transcriptional profiling of a multicellular organism by combinatorial indexing

Abstract excerpt

Conventional methods for profiling the molecular content of biological samples fail to resolve heterogeneity that is present at the level of single cells. In the past few years, single cell RNA sequencing has emerged as a powerful strategy for overcoming this challenge. However, its adoption has been limited by a paucity of methods that are at once simple to implement and cost effective to scale massively. Here, w...

Topics

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• Alternative Splicing
• Cell Lineage
• Gene Expression Profiling
• Gene Regulatory Networks
• Genetic Variation
• Models, Genetic
• Sequence Analysis, RNA
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

77570205-fc8f-5abd-8eef-4074b0283195

DOI

10.1101/104844