Article

Malignancy Ratio in Pediatric Patients with Hereditary Multi-ple Exostoses: True Association or Reporting Bias?

2025-10-11

Abstract excerpt

<h4>Background: </h4> Hereditary Multiple Exostoses (HME) is a rare autosomal dominant skel-etal disorder resulting from loss-of-function variants in the EXT1, EXT2, or EXT3 genes. While malignant transformation into chondrosarcoma is well documented, the inci-dence and characterization of non-skeletal malignancies in HME remain poorly de-fined. <h4>Objective:</h4> To comprehensively review the literature for repo...

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Literature Corpus work: 761c063a-0461-5a8e-9ca6-8a96f9e43dc7
DOI: 10.20944/preprints202510.0847.v1

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