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Biofilm/Persister/Stationary Phase Bacteria Cause More Severe Disease Than Log Phase Bacteria – I Biofilm Borrelia burgdorferi Not Only Display More Tolerance to Lyme Antibiotics But Also Cause More Severe Pathology In a Mouse Arthritis Model: Implications for Understanding Persistence, PTLDS and Treatment Failure

2018-10-11

Abstract excerpt

Lyme disease, caused by Borrelia burgdorferi, is the most common tick-borne illness in US and Europe. While most patients can be cured with a 2-4 week antibiotic therapy, about 10%-20% patients continue to suffer persistent symptoms of fatigue, pain or joint and muscle aches, and neurocognitive despite the treatment, a condition called post-treatment Lyme disease syndrome (PTLDS). The cause for PTLDS is unclear b...

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Literature Corpus work: 752dc1c6-66ee-5c21-ac2a-bc7cfcc870ee
DOI: 10.1101/440461

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