Article

Human <i>HPSE2</i> gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome

2023-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Rare early onset lower urinary tract disorders include defects of functional maturation of the bladder. Current treatments do not target the primary pathobiology of these diseases. Some have a monogenic basis, such as urofacial, or Ochoa, syndrome (UFS). Here, the bladder does not empty fully because of incomplete relaxation of its outflow tract, and subsequent urosepsis can cause kidney failure...

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Literature Corpus work: 6e1aaebd-262f-5d43-ad71-35b17b210497
DOI: 10.1101/2023.07.03.547034

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