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Article

Crystal structure of the human mARC1 p.M187K variant

2026-05-26

Abstract excerpt

The human mitochondrial amidoxime reducing component 1 (mARC1) is a molybdenum-dependent enzyme whose protein-coding variants confer protection against common metabolic liver diseases. Whereas the frequent A165T variant acts largely through accelerated cellular degradation, the basis of protection by the rarer M187K variant remains obscure, as it has been reported that there are no differences between the “wild-ty...

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Literature Corpus work
6dc21c78-2770-5c51-a18b-43247d304ddc
DOI
10.64898/2026.05.26.727831
Open publication

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Crystal structure of the human mARC1 p.M187K variantDOI 10.64898/2026.05.26.727831
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