Article

Emerging Combination Strategy: FANCI Inhibition Induces PARP1 Redistribution to Enhance Efficacy of PARP Inhibitors in Breast Cancer

2023-07-14

Abstract excerpt

<title>Abstract</title> <p>Background While PARP inhibitors have made advancements in the treatment of breast cancer, challenges such as chemotherapy resistance and limited application persist. FANCI, a DNA repair protein associated with breast cancer development, represents a potential target for novel combination therapeutic strategies. However, the role of FANCI in breast cancer and its impact on the efficacy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6a0e8f7f-8310-5f83-8446-b2109b363ddb
DOI: 10.21203/rs.3.rs-3131593/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Emerging Combination Strategy: FANCI Inhibition Induces PARP1 Redistribution to Enhance Efficacy of PARP Inhibitors in Breast CancerDOI 10.21203/rs.3.rs-3131593/v1Read

Development of the PARP inhibitor talazoparib for the treatment of advancedBRCA1andBRCA2mutated breast cancerSemantic proximity Read

Stumbling Blocks on the Path to Personalized Medicine in Breast Cancer: The Case of PARP Inhibitors for <i>BRCA1/2</i>-Associated CancersSemantic proximity Read

[Expert consensus on the clinical application of PARP inhibitors in breast cancer (2025 edition)].Semantic proximity Read

Pan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cellsSemantic proximity Read

Knocking down of FANCI expression inhibits the biological behavior of glioma and mediates apoptosis by downregulating the Akt/Bcl2 pathwaySemantic proximity Read

The Promise of Combining Inhibition of PI3K and PARP as Cancer TherapySemantic proximity Read

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCISemantic proximity Read

Epigenetic activation of HORMAD1 in basal-like breast cancer: role in Rucaparib sensitivitySemantic proximity Read

Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancerSemantic proximity Read

Overexpression of CHAF1A correlates with poor prognosis and tumor immunosuppressive microenvironment and resistance to treatment in cancerSemantic proximity Read

KLF4 promotes apoptosis evasion and PARP inhibitor resistance in BRCA2-mutated epithelial ovarian cancerSemantic proximity Read

Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitorSemantic proximity Read