Article

Mitigation of multi-scale biases in cell-type deconvolution for spatially resolved transcriptomics using HarmoDecon

2024-10-03

Abstract excerpt

The advent of spatially resolved transcriptomics (SRT) has revolutionized our understanding of tissue molecular microenvironments by enabling the study of gene expression in its spatial context. However, many SRT platforms lack single-cell resolution, necessitating cell-type deconvolution methods to estimate cell-type proportions in SRT spots. Despite advancements in existing tools, these methods have not addresse...

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Literature Corpus work: 69cb7f5e-122f-5ea3-982b-fa9751eb11a8
DOI: 10.1101/2024.10.02.616209

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