Skeletal diseases caused by mutations that affect collagen structure and function.

Abstract excerpt

Collagens form critical elements of extracellular matrices that provide mechanical strength to skeletal tissues and serve as a binding platform for cells of bone and cartilage. The formation of collagen-rich extracellular matrices is a complex process that involves intracellular and extracellular steps. Mutations in genes that encode individual chains of triple-helical collagens present in bone and cartilage are...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone Diseases
• Share to Cartilage
• Share to Collagen