Back to search

Article

A randomized double-blind Phase IIb trial to evaluate the efficacy of ChAd63-KH for the treatment of post kala-azar dermal leishmaniasis

2024-04-11

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> In a recent Phase IIa clinical trial, the candidate leishmaniasis vaccine ChAd63-KH was shown to be safe and immunogenic in Sudanese patients with post kala-azar dermal leishmaniasis (PKDL). However, its value as a stand-alone therapeutic was unknown. <h4>Methods</h4> To assess the therapeutic efficacy of ChAd63-KH, we conducted a “window of opportunity” randomized, double-b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
66fb9ba7-a6db-5962-804c-6c8c5034e273
DOI
10.1101/2024.04.11.24305597
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A randomized double-blind Phase IIb trial to evaluate the efficacy of ChAd63-KH for the treatment of post kala-azar dermal leishmaniasisDOI 10.1101/2024.04.11.24305597
Safety and immunogenicity of ChAd63-KH vaccine in post kala azar dermal leishmaniasis patients in SudanSemantic proximity
Severe visceral leishmaniasis in Ethiopia: outcomes, co-infections and mortality in a prospective real-world cohortSemantic proximity
Unraveling the Immune Response Dynamics of Leishmaniasis: Insights, Challenges, and Vaccine DevelopmentSemantic proximity
Pityriasis Rosea Shortly After mRNA-1273 COVID-19 VaccinationSemantic proximity
Vaccine candidates, immuno-dominant antigens, and potent vaccine adjuvants for preventing cutaneous leishmaniasis: a sysSemantic proximity
Post kala-azar dermal leishmaniasis: an unresolved mystery.Semantic proximity
Detection of LPG2 and GP63 Genes Sequencing in Patients with Cutaneous LeishmaniasisSemantic proximity
Post kala-azar dermal leishmaniasis: A threat to elimination program.Semantic proximity
Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive IndividualsSemantic proximity
Safety, effectiveness, and skin immune response in a controlled human infection model of sand fly transmitted cutaneous leishmaniasisSemantic proximity
Immunogenicity and immune modulatory effects of in silico predicted <i>L. donovani</i> candidate peptide vaccinesSemantic proximity
The potential impact of human visceral leishmaniasis vaccines on population incidenceSemantic proximity
Select a neighboring publication to make it the new centre.