Article

DoBSeqWF: A framework for sensitive detection of individual genetic variation in pooled sequencing data

2025-04-25

Abstract excerpt

<h4>Motivation</h4> Population screening for rare genetic diseases is limited by the high cost of next- generation sequencing. Double-batched sequencing (DoBSeq) is a cost-effective method for assigning rare variants to individuals using two-dimensional unique double- pooled sequencing. However, this method produces complex, high-depth sequencing data that requires a specialized workflow for efficient and reproduc...

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Literature Corpus work: 63e9442c-aede-5ac0-8800-4c5c70c84e9f
DOI: 10.1101/2025.04.23.25326275

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