Article

Activated Factor X delivered by Adeno-Associated virus significantly inhibited bleeding and alleviated hemophilia A/B arthropathy in hemophilia mice

2024-01-05

Abstract excerpt

<title>Abstract</title> <p>In hemophilia, deficient factor VIII or IX in hemophilia prevents activation of the common coagulation pathway, inhibiting conversion of FX to activated FXa required for thrombin generation. We hypothesized that delivering FXa could activate the common pathway and restore coagulation in hemophilia patients. In this study, we tried to deliver FXa by adeno-associated virus (AAV) for treat...

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Literature Corpus work: 63b9bfab-0e9e-5e23-9994-999d897a4ebd
DOI: 10.21203/rs.3.rs-3708399/v1

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Activated Factor X delivered by Adeno-Associated virus significantly inhibited bleeding and alleviated hemophilia A/B arthropathy in hemophilia miceDOI 10.21203/rs.3.rs-3708399/v1Read

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