Article

Landscape of Constitutional SOX4 Variation in Human Disorders

2024-01-04

Abstract excerpt

SOX proteins are transcription factors which play a role in regulating the development of pro-genitor cells and tissue differentiation. Twenty members are known, clustered in eight groups named A to H, and sharing a common DNA-binding domain called the HMG (high-mobility-group) box. Eleven of the SOX genes have been associated with genetic disorders so far, covering a broad spectrum of developmental diseases. SOX4...

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Literature Corpus work: 63b14ac7-f221-5311-9fa1-f9723b91f206
DOI: 10.20944/preprints202401.0342.v1

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