Generative AI and genetic analyses indicate metformin as a drug repurposing candidate for normal tension glaucoma

Abstract excerpt

<h4>Background</h4> The normal tension glaucoma (NTG) has limited drug options since current anti-glaucoma medications are mostly designed to decrease intraocular pressure (IOP). The emerging generative artificial intelligence (GAI) may provide an unprecedented approach for its drug repurposing research. <h4>Methods</h4> First, we iteratively interactivated with ChatGPT using 10 independent queries. Each query con...

Topics

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• Blood Pressure and Hypertension Studies
• Computational Biology
• Computational Drug Discovery Methods
• Deep Learning
• Drugs, Chinese Herbal
• Phenotype
• Rare Diseases
• Receptor Mechanisms and Signaling

Identifiers and source

Literature Corpus work

630900a5-7923-5b47-95d4-0d7cc31693d9

DOI

10.1101/2024.12.02.24318301