Article

A humanized Galleria mellonella model reveals prophage-mediated breakdown of colonization resistance against Salmonella

2026-06-25

Abstract excerpt

<h4>Background: </h4> Colonisation resistance provided by the gut microbiota is a critical barrier to pathogen invasion, yet its study in vivo is constrained by the complexity and cost of vertebrate models. Here, we developed a humanised Galleria mellonella infection model by inoculating wax moth larvae with complex human faecal microbiota. 16S rRNA gene sequencing confirmed stable, reproducible establishment of a...

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Literature Corpus work: 62b6358f-94da-5153-9e3c-25a09096c2cf
DOI: 10.64898/2026.06.24.734175

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