Article

Antisense oligonucleotides targeting the miR-29b binding site in the <i>GRN</i> mRNA increase progranulin translation

2022-01-13

Abstract excerpt

Heterozygous GRN (progranulin) mutations cause frontotemporal dementia (FTD) due to haploinsufficiency, and increasing progranulin levels is a major therapeutic goal. Several microRNAs, including miR-29b, negatively regulate progranulin protein levels. Antisense oligonucleotides (ASOs) are emerging as a promising therapeutic modality for neurological diseases, but strategies for increasing target protein levels a...

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Literature Corpus work: 5d502ee1-4ca5-5e16-91e0-fa072de5b598
DOI: 10.1101/2022.01.12.476053

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