Article

Underlying Genes and Molecular Mechanism of Keloids Investigated by Integrated Bioinformatics Analysis

2021-01-19

Abstract excerpt

<h4>Background: </h4> We aimed to identify the overlapping differentially expressed genes (DEGs) of keloids distinguished from normal scar and normal skin and relevant underlying mechanism using integrated bioinformatics methods. <h4>Methods: </h4> The expression profiles of 18 keloid samples, 7 normal skin and 5 normal scar, were obtained from the GSE7890, GSE44270, GSE92566, and GSE3189 datasets in the Gene Expr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5ccd038b-b714-5b69-8b13-f571ebcf935d
DOI: 10.21203/rs.3.rs-148691/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Underlying Genes and Molecular Mechanism of Keloids Investigated by Integrated Bioinformatics AnalysisDOI 10.21203/rs.3.rs-148691/v1Read

Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic modelSemantic proximity Read

Biological significance of genome‐wide DNA methylation profiles in keloidsSemantic proximity Read

Identification of Potential Therapeutic Target SPP1 and Related RNA Regulatory Pathway in Keloid Based on Bioinformatics AnalysisSemantic proximity Read

Integrated Transcriptomics and Machine Learning Unveil Diagnostic Signatures and Eosinophil-Related Immune Dysregulation in KeloidSemantic proximity Read

The Polygenic Map of Keloid Fibroblasts Reveals Fibrosis-Associated Gene Alterations in Inflammation and Immune Responses.Semantic proximity Read

Keloid-Specific Gene Expression Profiling for Accurate Diagnostic and Therapeutic ApplicationsSemantic proximity Read

Combined analyses of RNA-sequence and Hi-C along with GWAS loci-A novel approach to dissect keloid disorder genetic mechanism.Semantic proximity Read

Identification and characterization of bone/cartilage-associated signatures in common fibrotic skin diseasesSemantic proximity Read

Identification and analysis of dysregulated lncRNA and associated ceRNA in the pathogenesis of keloidSemantic proximity Read

Screening of keloid immune microenvironment-related genes and their effects on keloid proliferation and migrationSemantic proximity Read

Identification and validation of HOXD3 and UNC5C as molecular signatures in keloid based on weighted gene co-expression network analysisSemantic proximity Read

Immune‑related gene expression in skin, inflamed and keloid tissue from patients with keloidsSemantic proximity Read