Article

Myelin Mapping in the Human Brain Using an Empirical Extension of the Ridge Regression Theorem

2025-05-09

Abstract excerpt

<h4>Purpose</h4> Myelin water fraction (MWF) mapping in the central nervous system is a topic of intense research activity. One framework for this requires parameter estimation from a decaying biexponential signal. However, this is often an ill-posed nonlinear problem resulting in unreliable parameter estimates. For linear least-squares (LLS) problems, the ridge regression theorem (RRT) shows that a Tikhonov regu...

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Literature Corpus work: 5a5e1366-8039-5f0d-810b-45f0fa9db94a
DOI: 10.1101/2025.05.08.652955

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