Article

Heterogeneity of the placenta in health and disease explored through integrated histology, gene expression and modelling

2022-05-31

Abstract excerpt

Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Altered placental formation and functional capacity are major contributors to FGR pathogenesis. Relating placental structure to function across the placenta in healthy and FGR pregnancies remains largely unexplored but could improve understanding of placental diseases. We investigated integration of these parameters spatially i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59dfe5a6-9893-5290-bd1a-0edaae781164
DOI: 10.1101/2022.05.31.22275522

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity of the placenta in health and disease explored through integrated histology, gene expression and modellingDOI 10.1101/2022.05.31.22275522Read

Integrated Placental Modelling of Histology with Gene Expression to Identify Functional Impact on Fetal GrowthSemantic proximity Read

Placental Network Differences Among Obstetric Syndromes Identified With An Integrated Multiomics ApproachSemantic proximity Read

A unified developmental framework of the human placenta in its uterine environment in vivo and in vitroSemantic proximity Read

Mechanistic insights into the development of severe fetal growth restrictionSemantic proximity Read

Transcriptomic comparison of in vitro models of the human placentaSemantic proximity Read

Placental Dysfunction and Fetal Programming: The Importance of Placental Size, Shape, Histopathology, and Molecular CompositionSemantic proximity Read

The human placenta and its role in reproductive outcomes revisitedSemantic proximity Read

Placenta accreta spectrum disorder at single-cell resolution: a loss of boundary limits in the decidua and endotheliumSemantic proximity Read

Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growthSemantic proximity Read

Cross-species insights into placental evolution and diseases at the single-cell resolutionSemantic proximity Read

Biology and Pathophysiology of Placenta Accreta Spectrum DisorderSemantic proximity Read

A proteomic profile of the healthy human placentaSemantic proximity Read