Article

Evaluating the impact of <i>in silico</i> predictors on clinical variant classification

2021-08-10

Abstract excerpt

<h4>Background</h4> In silico evidence is important to consider when interpreting genetic variants. According to the ACMG/AMP, in silico evidence is applied at the supporting strength level using the PP3 and BP4 criteria, for pathogenic and benign evidence, respectively. While PP3 has been determined to be one of the most commonly applied criteria, less is known about the effect of these two criteria on variant...

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Literature Corpus work: 57f85681-8b81-5b2c-8507-7023969c9a84
DOI: 10.1101/2021.08.09.455612

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