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Unraveling Berberine's Multi-Target Mechanism in Combating NAFLD: A Network Pharmacology and In Vitro Study

2026-03-30

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<title>Abstract</title> <p>Background Non-alcoholic fatty liver disease (NAFLD) poses a global health burden with limited therapies. Berberine (BBR) shows promise against NAFLD, but its molecular mechanisms remain unclear. Methods Network pharmacology predicted BBR-NAFLD intersecting targets, followed by protein-protein interaction (PPI) network construction, GO/KEGG enrichment, and molecular docking. In vitro...

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Literature Corpus work
4fcda901-026c-5672-8065-444b6259899c
DOI
10.21203/rs.3.rs-9188982/v1
Open publication

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