Article

The Okur-Chung Neurodevelopmental Syndrome (OCNDS) mutation CK2 <sup>K198R</sup> leads to a rewiring of kinase specificity

2021-04-05

Abstract excerpt

Okur-Chung Neurodevelopmental Syndrome (OCNDS) is caused by heterozygous mutations to the CSNK2A1 gene, which encodes the alpha subunit of casein kinase II (CK2). The most frequently occurring mutation is lysine 198 to arginine (K198R). To investigate the impact of this mutation, we first generated a high-resolution phosphorylation motif of CK2 WT , including the first characterization of specificity for tyrosine...

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Literature Corpus work: 4ec4837c-816e-532b-9a43-712c7fa297f0
DOI: 10.1101/2021.04.05.438522

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