Article

Targeting KRAS G12C with Covalent Inhibitors

2021-12-21

Abstract excerpt

KRAS is the most frequently mutated oncogene in cancer. Following numerous attempts to inhibit KRAS spanning multiple decades, recent efforts aimed at covalently targeting the mutant cysteine of KRAS G12C have yielded very encouraging results. Indeed, one such molecule, sotorasib, has already received accelerated US Food and Drug Administration approval with phase III clinical trials currently underway. A second m...

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Literature Corpus work: 49abeafd-c082-5e67-ab47-ac12173018fe
DOI: 10.1146/annurev-cancerbio-041621-012549

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