Article

Non-Invasive Embryo Quality Assessment via Matrix-Optimized Untargeted LC-MS Metabolomics of Spent Embryo Culture Media and Weighted Ensemble Machine Learning

2026-08-04

Abstract excerpt

<h4>Background</h4> Non-invasive embryo quality assessment is a critical unmet need in assisted reproductive technology (ART). Preimplantation genetic testing for aneuploidy (PGT-A) is effective but requires invasive biopsy that may compromise embryo viability. Metabolomics of spent embryo culture media (SECM) offers a non-invasive alternative, yet analytical challenges—limited sample volume, high salt content, a...

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Literature Corpus work: 493d5012-646e-5530-b2d0-d08e3bae8e10
DOI: 10.64898/2026.07.30.741666

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