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Cross cohort oral microbiome meta-analysis identifies shared OPMD OSCC dysbiosis while machine learning exposes limits of OSCC classifier transportability

2026-08-28

Abstract excerpt

Oral potentially malignant disorders (OPMDs) precede a subset of oral squamous cell carcinomas (OSCCs), but microbiome studies are difficult to compare because disease subtypes, sampling, sequencing regions and cohorts differ. We hypothesized that harmonized reprocessing of independent 16S rRNA datasets would identify reproducible microbial changes shared across OPMD and OSCC, while cohort-level validation would r...

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Literature Corpus work: 48340461-c4a6-59ce-b5ec-95a76ea7f926
DOI: 10.64898/2026.08.28.747776

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