Enhancing Infectious Intestinal Disease diagnosis through metagenomic and metatranscriptomic sequencing of over 1000 human diarrhoeal samples

Abstract excerpt

Fundamental issues in the traditional surveillance of diarrhoeal disease need to be addressed. The limitations of traditional microbiological diagnostic methods often mean that the cause of diarrhoea remains unknown, especially for novel or difficult-to-isolate pathogens. Sequencing samples directly, without isolating pathogens, would address this issue. However, we must ensure that sequencing also captures pathog...

Topics

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• Animal Virus Infections Studies
• Bacteriophages and microbial interactions
• Clostridium difficile and Clostridium perfringens research
• Gut microbiota and health
• Mycobacterium research and diagnosis
• Parasitic Infections and Diagnostics
• Salmonella and Campylobacter epidemiology
• Viral gastroenteritis research and epidemiology

Identifiers and source

Literature Corpus work

46e0977b-77a8-5819-b4c3-fe3b08b9ed86

DOI

10.1101/2023.04.03.23288067