Article

Momelotinib is a highly potent inhibitor of FLT3-mutant AML

2021-03-18

Abstract excerpt

Kinase activating mutation in FLT3 is the most frequent genetic lesion associated with poor prognosis in acute myeloid leukemia (AML). Therapeutic response to FLT3 tyrosine kinase inhibitor (TKI) therapy is dismal, and many patients relapse even after allogenic stem cell transplantation. Despite the introduction of more selective FLT3 inhibitors, remissions are short-lived, and patients show progressive disease af...

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Literature Corpus work: 4459e657-4f54-5890-ba12-b8126179381e
DOI: 10.1101/2021.03.18.436047

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